Phosphatidic Acids (ammonium salt) |
| Katalog-Nr.GC91806 |
Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Phosphatidic acid is a phospholipid and an intermediate in glycerolipid biosynthesis.[1] It is a transient intermediate in the synthesis of various phospholipid species that is synthesized de novo in cells via multiple routes, including the glycerol-3 phosphate and dihydroxyacetone phosphate pathways, enzymatic conversion of phosphatidylcholine by phospholipase D, and acetylation of lysophosphatidic acid by lysoPA-acyltransferase, among others.2,3 It has roles in shaping cellular membranes, cellular signaling, vesicle fission and fusion, as well as mitochondrial division and fusion. It stimulates respiratory burst in neutrophils independent of diacylglycerol and activates monoacylglycerol acyltransferase, phospholipase C (PLC), Ras, and phosphatidylinositol 4-phosphate (PIP4) kinase in several cell lines. This product contains phosphatidic acid molecular species with primarily C16:0 and C18:1 fatty acyl chain lengths.
References:
[1].Athenstaedt, K., and Daum, G.Phosphatidic acid, a key intermediate in lipid metabolismEur. J. Biochem.266(1)1-16(1999).
[2].Járai, Z., Wagner, J.A., Goparaju, S.K., et al.Cardiovascular effects of 2-arachidonoyl glycerol in anesthetized miceHypertension35679-684(2000).
[3].Kameoka, S., Adachi, Y., Okamoto, K., et al.Phosphatidic acid and cardiolipin coordinate mitochondrial dynamicsTrends Cell Biol.28(1)67-76(2018).
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