PLX7922 |
Katalog-Nr.GC64828 |
PLX7922, ein RAF-Inhibitor, kann an BRAFV600E binden. PLX7922 hemmt pERK in BRAFV600E-Zelllinien und aktiviert pERK in mutierten NRAS-Zelllinien.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1638772-61-8
Sample solution is provided at 25 µL, 10mM.
PLX7922, a RAF inhibitor, can bind with BRAFV600E. PLX7922 inhibits pERK in BRAFV600E cell lines, and activates pERK in mutant NRAS cell lines[1].
PLX7922 (1-1000 nM) inhibits pERK in BRAFV600E cell lines, activates pERK in mutant NRAS cell lines (B9 and IPC-298)[1].
[1]. Zhang C, et, al. RAF inhibitors that evade paradoxical MAPK pathway activation. Nature. 2015 Oct 22;526(7574):583-6.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *