Pom-8PEG |
| Katalog-Nr.GC63149 |
Pom-8PEG, ein E3-Ligase-Ligand-Linker-Konjugat, enthÄlt einen Cereblon (CRBN)-Liganden fÜr die E3-Ubiquitin-Ligase und einen 8-Einheiten-PEG-Linker. Pom-8PEG kann bei der Synthese von PROTAC, wie dem IDO1-PROTAC-Abbauer, verwendet werden.
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Cas No.: 2488761-03-9
Sample solution is provided at 25 µL, 10mM.
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Pom-8PEG, an E3 ligase ligand-linker conjugate, incorporates a cereblon (CRBN) ligand for the E3 ubiquitin ligase and an 8-unit PEG linker. Pom-8PEG can be used in the synthesis of PROTAC, such as IDO1 PROTAC degrader[1].
[1]. Hu M, et al. Discovery of the first potent proteolysis targeting chimera (PROTAC) degrader of indoleamine 2,3-dioxygenase 1. Acta Pharm Sin B. 2020;10(10):1943-1953.
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