Pomalidomide-amino-PEG4-NH2 hydrochloride |
| Katalog-Nr.GC63811 |
Pomalidomid-Amino-PEG4-NH2-Hydrochlorid ist ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat, das den Cereblon-Liganden auf Pomalidomid-Basis und einen in der PROTAC-Technologie verwendeten Linker enthÄlt.
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Cas No.: 2331259-45-9
Sample solution is provided at 25 µL, 10mM.
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Pomalidomide-amino-PEG4-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and a linker used in PROTAC technology[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.
[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985.
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