PPACK (trifluoroacetate salt) (Synonyms: Pebac, DPhenylalanylprolylarginyl Chloromethyl Ketone) |
Katalog-Nr.GC47966 |
An antithrombin peptide
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
PPACK is a synthetic peptide derivative that irreversibly and specifically inhibits thrombin-
1.Kovach, I.M., Kelley, P., Eddy, C., et al.Proton bridging in the interactions of thrombin with small inhibitorsBiochemistry48(30)7296-7304(2009) 2.Bode, W., Turk, D., and Karshikov, A.The refined 1.9-Å x-ray crystal structure of D-Phe-Pro-Arg chloromethylketone-inhibited human α-thrombin: Structure analysis, overall structure, electrostatic properties, detailed active-site geometry, and structure-function relationshipsProtein Science1(4)426-471(1992) 3.Hanson, S.R., and Harker, L.A.Interruption of acute platelet-dependent thrombosis by the synthetic antithrombin D-phenylalanyl-L-prolyl-L-arginyl chloromethyl ketoneProceedings of the National Academy of Sciences of the United States of America85(9)3184-3488(1988) 4.Lyon, M.E., Fine, J.S., Henderson, P.J., et al.D-phenylalanyl-L-prolyl-L-arginine chloromethyl ketone (PPACK): Alternative anticoagulant to heparin salts for blood gas and electrolyte specimensClinical Chemistry41(7)1038-1041(1995) 5.Liu, J.F., Hou, S.M., Tsai, C.H., et al.Thrombin induces heme oxygenase-1 expression in human synovial fibroblasts through protease-activated receptor signaling pathwaysArthritis Research & Therapy14(2)R91(2012)
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