Prochloraz (Synonyms: BTS-40542) |
| Katalog-Nr.GC44686 |
Prochloraz ist ein Imidazol-Antimykotikum, das die Ergosterol-Biosynthese durch Hemmung der Cytochrom-P450-abhÄngigen 14α-Demethylierung von Lanosterol hemmt, was zu einer ZerstÖrung der Pilzzellmembran und zum Zelltod fÜhrt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 67747-09-5
Sample solution is provided at 25 µL, 10mM.
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Prochloraz is an imidazole antifungal that inhibits ergosterol biosynthesis via inhibition of the cytochrome P450-dependent 14α-demethylation of lanosterol, which results in disruption of the fungal cell membrane and cell death. It inhibits human placenta microsomal aromatase in vitro (IC50 = 40 nM). Prochloraz also acts as an antagonist of the estrogen receptor (ER) and androgen receptor (AR) (IC50s = 25 and 4 μM, respectively) as well as activates the aryl hydrocarbon receptor (AhR; EC50 = 1 μM). In vivo, prochloraz (250 mg/kg) reduces the weight of seminal vesicles in intact male rats and of seminal vesicles, ventral prostate, and bulbourethral glands in castrated testosterone-treated male rats. It also reduces testosterone levels and increases progesterone levels in male rat pups following administration of a 30 mg/kg per day dose to pregnant females during gestation. Formulations containing prochloraz have been used to control fungal growth in mushroom cultivation.
| Cas No. | 67747-09-5 | SDF | |
| Überlieferungen | BTS-40542 | ||
| Canonical SMILES | ClC1=C(OCCN(CCC)C(N2C=NC=C2)=O)C(Cl)=CC(Cl)=C1 | ||
| Formula | C15H16Cl3N3O2 | M.Wt | 376.7 |
| Löslichkeit | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml | Storage | Store at 0-6°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6546 mL | 13.2732 mL | 26.5463 mL |
| 5 mM | 0.5309 mL | 2.6546 mL | 5.3093 mL |
| 10 mM | 0.2655 mL | 1.3273 mL | 2.6546 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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