Prostaglandin F2α-d9 (Synonyms: Dinoprostd9)

Prostaglandin F_2α-d₉ (PGF_2α-d₉) contains nine deuterium atoms at the 17, 17', 18, 18', 19, 19', 20, 20, and 20 positions. It is intended for use as an internal standard for the quantification of PGF_2α by GC- or LC-mass spectrometry. PGF_2α is a widely distributed PG occurring in many species.^1,2,3 It causes contraction of vascular, bronchial, intestinal, and myometrial smooth muscle, and also exhibits potent luteolytic activity.¹ PGF_2α exerts its receptor mediated physiological activity at 50-100 nM.¹ Maximal ovine myometrial contraction can be achieved at 125 nM PGF_2α in vitro.⁴

1.Samuelsson, B., Goldyne, M., GranstrÖm, E., et al.Prostaglandins and thromboxanesAnnu. Rev. Biochem.47997-1029(1978) 2.Speroff, L., and Ramwell, P.W.Prostaglandins in reproductive physiologyAm. J. Obstet. Gynecol.107(7)1111-1130(1970) 3.Watanabe, K., Iguchi, Y., Iguchi, S., et al.Stereospecific conversion of prostaglandin D2 to (5Z,13E)-(15S)-9α,-11β,15-trihydroxyprosta-5,13-dien-1-oic acid (9α,11β-prostaglandin F2) and of prostaglandin H2 to prostaglandin F2α by bovine lung prostaglandin F synthaseProc. Natl. Acad. Sci. U.S.A.83(6)1583-1587(1986) 4.Crankshaw, D.J., and Gaspar, V.Pharmacological characterization in vitro of prostanoid receptors in the myometrium of nonpregnant ewesJ. Reprod. Fertil.103(1)55-61(1995)