PROTAC SGK3 degrader-1 (Synonyms: SGK3-PROTAC1) |
| Katalog-Nr.GC39426 |
PROTAC SGK3-Degrader-1 (SGK3-PROTAC1) ist ein potenter SKG3-Degrader auf der Basis von von Hippel-Lindau-Liganden. PROTAC SGK3 Degrader-1 (0,3 μM) induziert 50 % Abbau von endogenem SGK3 innerhalb von 2 Stunden, wobei maximal 80 % Abbau innerhalb von 8 Stunden beobachtet werden, begleitet von einem Verlust der Phosphorylierung von NDRG1 (einem SGK3-Substrat).
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Cas No.: 2381320-35-8
Sample solution is provided at 25 µL, 10mM.
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PROTAC SGK3 degrader-1 (SGK3-PROTAC1), is a potent SKG3 degrader based on PROTAC. PROTAC SGK3 degrader-1 (0.3 μM) induces 50% degradation of endogenous SGK3 within 2 hours, with maximal 80% degradation observed within 8 hours, accompanied by a loss of phosphorylation of NDRG1( an SGK3 substrate)[1].
[1]. Tovell H, et al. Design and Characterization of SGK3-PROTAC1, an Isoform Specific SGK3 Kinase PROTAC Degrader. ACS Chem Biol. 2019 Sep 20;14(9):2024-2034.
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