Protease-Activated Receptor-4 |
| Katalog-Nr.GC33429 |
Der Protease-aktivierte Rezeptor-4 ist der Agonist des Proteinase-aktivierten Rezeptors-4 (PAR4).
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Cas No.: 245443-52-1
Sample solution is provided at 25 µL, 10mM.
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Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold[1]. GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips[2].
[1]. Moschonas IC, et al. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets. 2017 Mar 7:1-10. doi: 10.1080/09537104.2017.1282607. [Epub ahead of print] [2]. Huang SC, et al. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014 Feb 10;189:46-50.
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