R 568 hydrochloride (Synonyms: KRN 568, NPS R-568, Tecalcet) |
| Katalog-Nr.GC17700 |
R 568-Hydrochlorid (R 568-Hydrochlorid), eine oral wirksame calcimimetische Verbindung, moduliert allosterisch und positiv den Calcium-Sensing-Rezeptor (CaSR).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 177172-49-5
Sample solution is provided at 25 µL, 10mM.
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Tecalcet Hydrochloride (R 568 Hydrochloride), an orally active calcimimetic compound, allosterically and positively modulates the calcium-sensing receptor (CaSR). Tecalcet Hydrochloride (R 568 Hydrochloride) increases the sensitivity to activation by extracellular Ca2+[1][2][3].
References:
[1]. Wada, M., et al. The calcimimetic compound NPS R-568 suppresses parathyroid cell proliferation in rats with renal insufficiency. Control of parathyroid cell growth via a calcium receptor. Journal of Clinical Investigation 100(12), 2977-2983 (1997).
[2]. Nemeth, E.F., et al. The parathyroid calcium receptor: a novel therapeutic target for treating hyperparathyroidism. Pediatr.Nephrol. 10(3), 275-279 (1996).
[3]. Nemeth, E.F., et al. Calcimimetics with potent and selective activity on the parathyroid calcium receptor. Proceedings of the National Academy of Sciences of the United States of America 95(7), 4040-4045 (1998).
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