(R)-BMS-816336 |
| Katalog-Nr.GC39029 |
(R)-BMS-816336 (Verbindung 6n-1) ist ein potenter und oral aktiver Inhibitor des Enzyms 11β-Hydroxysteroiddehydrogenase Typ 1 (11β-HSD1) von Mensch, Maus und Krabbenesser mit IC50-Werten von 14,5 nM, 50,3 nM und 16 nM bzw. .
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1009583-83-8
Sample solution is provided at 25 µL, 10mM.
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(R)-BMS-816336 (Compound 6n-1) is a potent and orally active inhibitor of human, mouse and cynomolgus monkey 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) enzyme with IC50s of 14.5 nM, 50.3 nM and 16 nM, respectively [1].
[1]. Ye XY, et al. Discovery of Clinical Candidate 2-((2S,6S)-2-Phenyl-6-hydroxyadamantan-2-yl)-1-(3'-hydroxyazetidin-1-yl)ethanone [BMS-816336], an Orally Active Novel Selective 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitor. J Med Chem. 2017 Jun 22;60(12):4932-4948.
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