RECQL5-IN-1 |
| Katalog-Nr.GC64100 |
RECQL5-IN-1 (Verbindung 4a) wirkt als oral wirksamer RECQL5-Inhibitor (der sowohl auf die enzymatische als auch auf die nichtenzymatische DomÄne abzielt). RECQL5-IN-1 ist ein potenter Inhibitor der RECQL5-Helikase-AktivitÄt (IC50 = 46,3 nM). RECQL5-IN-1 hemmt RECQL5-WT-Zellen und RECQL5-KO2-Zellen mit IC50s von 4,8 μM bzw. 19,6 μM. RECQL5-IN-1 kann fÜr die Erforschung von Brustkrebs verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2718170-45-5
Sample solution is provided at 25 µL, 10mM.
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RECQL5-IN-1 (Compound 4a) acts as an orally effective RECQL5 inhibitor (targeting both enzymatic and nonenzymatic domain). RECQL5-IN-1 is a potent inhibitor of RECQL5 helicase activity (IC50=46.3 nM). RECQL5-IN-1 inhibits RECQL5-WT cells and RECQL5-KO2 cells with IC50s of 4.8 μM and 19.6 μM, respectively. RECQL5-IN-1 can be used for the research of breast cancer[1].
[1]. Saikat Chakraborty, et al. Targeting RECQL5 Functions, by a Small Molecule, Selectively Kills Breast Cancer in Vitr o and in Vivo. J Med Chem. 2021 Feb 11;64(3):1524-1544.
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