(3-Carboxypropyl)trimethylammonium chloride |
| Katalog-Nr.GC33797 |
(3-Carboxypropyl)trimethylammoniumchlorid ist eine angiopathische Substanz, die als intermediÄrer Metabolit von Darmmikrobiota produziert wird, die sich von Carnitin in diÄtetischem rotem Fleisch ernÄhren.
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Cas No.: 6249-56-5
Sample solution is provided at 25 µL, 10mM.
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(3-Carboxypropyl)trimethylammonium chloride is angiopathic substance produced as an intermediary metabolite by gut microbiota that feed on carnitine in dietary red meat.
(3-Carboxypropyl)trimethylammonium chloride is produced as an intermediary metabolite by gut microbes of L-Carnitine to TMAO[1]. (3-Carboxypropyl)trimethylammonium chloride is implicated in arteriosclerosis and long-term cardiovascular death[2].
[1]. Koeth RA, et al. γ-Butyrobetaine is a proatherogenic intermediate in gut microbial metabolism of L-carnitine to TMAO. Cell Metab. 2014 Nov 4;20(5):799-812. [2]. Susumu Ogawa, et al. The Dynamics of Carnitine, γ-butyrobetaine and Trimethylamine N-oxide in Diabetics and the Effects of Changes in Renal Function. Ogawa et al., J Nephrol Ren Dis 2017, 1:2
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