A23187 (calcium magnesium salt) (Synonyms: Calcimycin) |
Katalog-Nr.GC42659 |
A23187 is a divalent cation ionophore.
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Sample solution is provided at 25 µL, 10mM.
A23187 is a divalent cation ionophore. While more selective for Mn2+, it is commonly used to facilitate the movement of Ca2+ into cells, triggering the activation of intracellular calcium-dependent pathways.[1] A23187 is also used to produce apoptosis through calcium overload, as occurs during hypoxic or oxidative stress.[2],[3]
Reference:
[1]. Sullivan, T.J., and Parker, C.W. Pharmacologic modulation of inflammatory mediator release by rat mast cells. Am. J. Pathol. 85(2), 437-464 (1976).
[2]. Maecker, H.T., Hedjbeli, S., Alzona, M., et al. Comparison of apoptosis signaling through T cell receptor, Fas, and calcium ionophore. Exp. Cell Res. 222(1), 95-102 (1996).
[3]. Cho, S.Y., Lee, J.H., Bae, H.D., et al. Transglutaminase 2 inhibits apoptosis induced by calcium-overload through down-regulation of Bax. Exp. Mol. Med. 42(9), 639-650 (2010).
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