Atrimustine (Bestrabucil) |
| Katalog-Nr.GC34155 |
Atrimustin (Bestrabucil) ist ein Konjugat aus Chlorambucil und &7#946;-Estradiolbenzoat mit Antitumorwirkung.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 75219-46-4
Sample solution is provided at 25 µL, 10mM.
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Atrimustine is a conjugate of chlorambucil and β-estradiol benzoate with the antitumor activity.
Atrimustine (Bestrabucil), a conjugate of chlorambucil and β-estradiol benzoate, has high affinity for tumor cells and enhancesthe antitumor activity of chlorambucil[1].The effect of Atrimustine (Bestrabucil), a benzoate of an estradiol-chlorambucil conjugate, is examined on the production of growth factor(s) by Shionogi carcinoma 115 (SC-115) cells, an androgen-responsive cultured cancer cell line. At Atrimustine concentrations of 100 nM-10 μM, concentration-dependent inhibition of growth factor production by SC-115 cells can be demonstrated by 3H-thymidine uptake assay[2].
[1]. Ezaki K, et al. A combination trial of human lymphoblastoid interferon and bestrabucil (KM2210) for adult T-cell leukemia-lymphoma. Cancer. 1991 Aug 15;68(4):695-8. [2]. Akaza H, et al. Inhibitory effects of bestrabucil, a conjugate of chlorambucil and estradiol, on the production of androgen-induced growth factor(s) by Shionogi carcinoma 115 cells. Int J Urol. 1994 Mar;1(1):67-73.
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