C16 Ceramide-d7 (d18:1-d7/16:0) (Synonyms: Cer-d7 (d18:1-d7/16:0), Ceramide-d7 (d18:1-d7/16:0), N-hexadecanoyl-D-erythro-Sphingosine-d7) |
| Katalog-Nr.GC46976 |
An internal standard for the quantification of C-16 ceramide
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Cas No.: 1840942-13-3
Sample solution is provided at 25 µL, 10mM.
C16 Ceramide-d7 is intended for use as an internal standard for the quantification of C16 ceramide by GC- or LC-MS. C16 Ceramide is an endogenous ceramide, generated by ceramide synthase 6 (CerS6), that acts as a lipid second messenger to regulate apoptosis and stress signaling.1 Accumulation of C16 ceramide through PPMP (30 μM) or MAPP (50 μM) treatment or from addition of 100 μM synthetic C16 ceramide induces apoptosis in neutrophil cultures via caspase-3 activation.2
1.White-Gilbertson, S., Mullen, T., Senkal, C., et al.Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase 3 in colon cancer cellsOncogene28(8)1132-1141(2009) 2.Seumois, G., Fillet, M., Gillet, L., et al.De novo C16- and C24-ceramide generation contributes to spontaneous neutrophil apoptosisJ. Leukoc. Biol.81(6)1477-1486(2007)
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