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CAY10561 (Synonyms: Pyrazolylpyrrole ERK Inhibitor)

Katalog-Nr.GC43167

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes.

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CAY10561 Chemische Struktur

Cas No.: 933786-58-4

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500μg
34,00 $
Auf Lager
1mg
66,00 $
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5mg
274,00 $
Auf Lager
10mg
479,00 $
Auf Lager

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

The extracellular signal-regulated kinase (ERK) signal transduction pathway regulates a diverse array of cellular processes. These processes include cell survival, proliferation, motility, and differentiation and are constitutively activated in cancers involving lung, colon, pancreas, kidney, and ovary. CAY10561 is a potent, ATP-competitive inhibitor of ERK2 (Ki = 2 nM). This compound is highly selective for ERK2 compared to other kinases such as PKA (Ki = 0.39 µM) and JNK3 (Ki = 4 µM). CAY10561 inhibits proliferation of COLO 205 cells with an IC50 value of 0.54 µM.

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