Deltorphin I (Synonyms: Deltorphin 1; Deltorphin C) |
| Katalog-Nr.GC12143 |
Deltorphin I ist ein δ-Opioid-Rezeptoragonist mit hoher AffinitÄt und SelektivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 122752-15-2
Sample solution is provided at 25 µL, 10mM.
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Deltorphin I is a δ-opioid receptor agonist with high affinity and selectivity.
Twice daily administration of Deltorphin I (20μg/mouse) for 4 days produces tolerance to Deltorphin I analgesia, as shown by the decrease in the analgesic response. The peak analgesic response to Deltorphin I (20 μg/mouse) at 10 min after injections is decreased from 8.36±0.28 s (the 1st day) to 4.53±0.14 s (the 4th day) markedly. Concurrent treatment of Melatonin (0.5, 1 and 2.5 mg/kg) and Deltorphin I (20 μg/mouse) twice daily for 4 days can attenuate the tolerance to Deltorphin I analgesia (P<0.05, <0.05 and <0.05), and this effect is dose dependent[1].
References:
[1]. Dai X, et al. Melatonin attenuates the development of antinociceptive tolerance to delta-, but not to mu-opioid receptor agonist in mice. Behav Brain Res. 2007 Aug 22;182(1):21-7.
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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