E3 Ligase Ligand-Linker Conjugates 20 (Synonyms: Cereblon Ligand-Linker Conjugates 2; E3 Ligase Ligand-Linker Conjugates 20) |
Katalog-Nr.GC33390 |
E3-Ligase-Ligand-Linker-Konjugate 20 (Cereblon-Ligand-Linker-Konjugate 2), ein synthetisiertes E3-Ligase-Ligand-Linker-Konjugat, das den auf Thalidomid basierenden Cereblon-Liganden und einen Linker enthÄlt, kann bei der Synthese von PROTACs verwendet werden.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1950635-15-0
Sample solution is provided at 25 µL, 10mM.
E3 Ligase Ligand-Linker Conjugates 20 is a degron-linker (refer to Compound DL7-TL). The PROTAC linker is bound lo at least one targeting ligand.
Degron-linker-targeting ligand, wherein the linker is covalently bound lo at least one degron and at least one targeting ligand, the degron is a compound capable of binding to an ubiquitin ligase such as an E3 ubiquitin ligase (e g, cereblon), and the targeting ligand is capable of binding to the targeted protein (s)[1].
[1]. James Bradner, et al. Methods to induce targeted protein degradation through bifunctional molecules. WO 2017024317 A2.
Average Rating: 5
(Based on Reviews and 34 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *