EB-3D |
| Katalog-Nr.GC39377 |
EB-3D ist ein potenter und selektiver Hemmer der Cholinkinase α (ChoKα) mit einem IC50-Wert von 1 μM fÜr ChoKα1. EB-3D Übt Wirkungen auf die ChoKα-Expression, die AMPK-Aktivierung, die Apoptose, den Stress des endoplasmatischen Retikulums und den Lipidstoffwechsel aus. EB-3D zeigt eine starke antiproliferative AktivitÄt in einer Reihe von T-LeukÄmie-Zelllinien. Anti-Krebs-AktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1839150-63-8
Sample solution is provided at 25 µL, 10mM.
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EB-3D is a potent and selective choline kinase α (ChoKα) inhibitor, with an IC50 of 1 μM for ChoKα1. EB-3D induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. EB-3D exhibits a potent antiproliferative activity in a panel of T-leukemia cell lines. Anti-cancer activity[1][2][3].
[1]. Mariotto E, et al. EB-3D a novel choline kinase inhibitor induces deregulation of the AMPK-mTOR pathway and apoptosis in leukemia T-cells. Biochem Pharmacol. 2018 Sep;155:213-223. [2]. Sola-Leyva A, et al. Choline kinase inhibitors EB-3D and EB-3P interferes with lipid homeostasis in HepG2 cells. Sci Rep. 2019 Mar 25;9(1):5109. [3]. Schiaffino-Ortega S, et al. Design, synthesis, crystallization and biological evaluation of new symmetrical biscationic compounds as selective inhibitors of human Choline Kinase α1 (ChoKα1).
Average Rating: 5 (Based on Reviews and 19 reference(s) in Google Scholar.)
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