Flavokawain B |
| Katalog-Nr.GC41261 |
Flavokawain B (Flavokavain B) ist ein aus den Wurzelextrakten der Kava-Kava-Pflanze isoliertes Chalcon und ein starker Apoptoseinduktor zur Hemmung des Wachstums verschiedener Krebszelllinien. Flavokawain B (Flavokavain B) zeigt eine starke antiangiogene AktivitÄt. Flavokawain B (Flavokavain B) hemmt die Migration von Endothelzellen des menschlichen Gehirns (HUVEC) und die Bildung von RÖhren mit sehr niedrigen und nicht toxischen Konzentrationen.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1775-97-9
Sample solution is provided at 25 µL, 10mM.
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Flavokawain B is a natural chalcone first isolated from extracts of kava roots. It induces apoptosis in androgen receptor-negative, hormone-refractory prostate cancer cell lines (IC50s = 32, 48, 6.2, and 3.9 µM for LAPC4, LNCaP, PC-3, and DU145 cells, respectively, treated for 48 hours), with increased expression of the proapoptotic protein Bim. Flavokawain B increases Bim expression and inhibits growth of DU145 xenografts in mice. It also increases Bim expression, promotes apoptosis, and induces cell cycle arrest in uterine leiomyosarcoma cells. However, flavokawain B is hepatotoxic, triggering oxidative stress, inhibiting NF-κB signaling, and activating MAPK pathways, culminating in HepG2 and L-02 cell death (LD50s = 15 and 32 µM, respectively).
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