GW806742X |
| Katalog-Nr.GC36203 |
GW806742X, ein ATP-Mimetikum und ein potenter MLKL (Mixed Lineage Kinase Domain-Like Protein)-Inhibitor, bindet die MLKL-Pseudokinase-DomÄne mit einem Kd von 9,3 μM.
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Cas No.: 579515-63-2
Sample solution is provided at 25 µL, 10mM.
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GW806742X is a Mixed Lineage Kinase Domain-Like protein (MLKL) inhibitor which binds the MLKL pseudokinase domain with a Kd value of 9.3 μM and has anti-necroptosis activity. GW806742X has activity against VEGFR2[1][2]. Kd: 9.3 μM (MLKL)[1]
[1]. Hildebrand JM, et al. Activation of the pseudokinase MLKL unleashes the four-helix bundle domain to induce membrane localization and necroptotic cell death. Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15072-7. [2]. Yan B, et al. Discovery of a new class of highly potent necroptosis inhibitors targeting the mixed lineagekinase domain-like protein. Chem Commun (Camb). 2017 Mar 28;53(26):3637-3640.
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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