Okanin |
| Katalog-Nr.GC36794 |
Okanin, wirksamer Bestandteil des BlÜtentees Coreopsis tinctoria, dÄmpft die LPS-induzierte Mikroglia-Aktivierung durch Hemmung der TLR4/NF-κB-Signalwege.
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Cas No.: 484-76-4
Sample solution is provided at 25 µL, 10mM.
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Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways[1]. TLR4 p65
Okanin significantly inhibits LPS-induced TLR4 expression in BV-2 cells. Okanin inhibits the translocation of the NF-κB p65 subunit from the cytosol to the nucleus. Okanin significantly suppresses LPS-induced iNOS expression and also inhibites IL-6 and TNF-α production and mRNA expression in LPS-stimulated BV-2 cells[1].
[1]. Hou Y, et al. Okanin, effective constituent of the flower tea Coreopsis tinctoria, attenuates LPS-induced microglial activation through inhibition of the TLR4/NF-κB signaling pathways. Sci Rep. 2017 Apr 3;7:45705.
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