SNIPER(ER)-110 |
Katalog-Nr.GC37657 |
SNIPER(ER)-110 besteht aus einem IAP-Liganden und einem Östrogen-Liganden, die durch einen Linker verbunden sind. SNIPER(ER)-51 induziert den Östrogenrezeptor (ER)-Proteinabbau mit DC50s von <3 nM und 7,7 nM nach 4 h bzw. 48 h.
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Cas No.: 2241690-03-7
Sample solution is provided at 25 µL, 10mM.
SNIPER(ER)-110 consists of a cIAP1 ligand and an estrogen ligand, connected by a linker. SNIPER(ER)-51 induces estrogen receptor (ER) protein degradation with DC50s of <3 nM and 7.7 nM after 4 h and 48 h, respectively[1].
[1]. Ohoka N, et al. Derivatization of inhibitor of apoptosis protein (IAP) ligands yields improved inducers of estrogen receptor α degradation. J Biol Chem. 2018 May 4;293(18):6776-6790.
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