DNA2 inhibitor C5 |
| Katalog-Nr.GC38207 |
Der DNA2-Inhibitor C5 ist ein potenter, kompetitiver und spezifischer Inhibitor der DNA2-NukleaseaktivitÄt mit einem IC50-Wert von 20 μM. DNA2-Inhibitor C5 hemmt Nuklease, DNA-abhÄngige ATPase, Helikase und DNA-BindungsaktivitÄten von DNA2. Der DNA2-Inhibitor C5 ist eine vielversprechende Leitsubstanz zur Entwicklung von Sensibilisatoren fÜr Krebs-Chemotherapeutika, die Replikationsstress verursachen.
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Cas No.: 35973-25-2
Sample solution is provided at 25 µL, 10mM.
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DNA2 inhibitor C5 is a potent, competitive and specific inhibitor of DNA2 nuclease activity with an IC50 of 20 μM. DNA2 inhibitor C5 inhibits nuclease, DNA dependent ATPase, helicase, and DNA binding activities of DNA2. DNA2 inhibitor C5 is a promising lead compound to develop sensitizers for cancer chemotherapeutics that cause replication stress[1].
[1]. Binghui Shen, et al. Dna2 inhibitors for cancer treatment. US20170226063A1.
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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