VU0364770 hydrochloride |
| Katalog-Nr.GC38597 |
VU0364770-Hydrochlorid ist ein selektiver und potenter positiver allosterischer Modulator (PAM) von mGlu4.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1414842-70-8
Sample solution is provided at 25 µL, 10mM.
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VU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1.1 μM at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17.9 μM and PAM activity at mGlu6 with a potency of 6.8 μM. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8.5 and 0.72 μM for human MAO-A and human MAO-B, respectively[1].
[1]. Jones CK, et al. The metabotropic glutamate receptor 4-positive allosteric modulator VU0364770 produces efficacy alone and in combination with L-DOPA or an adenosine 2A antagonist in preclinical rodent models of Parkinson's disease. J Pharmacol Exp Ther. 2012 Feb;340(2):404-21.
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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