KYP 2047 |
| Katalog-Nr.GC50403 |
KYP 2047 ist ein potenter und BBB-durchdringender Prolyl-Oligopeptidase (POP)-Inhibitor mit einem Ki-Wert von 0,023 nM. KYP 2047 reduziert die Glioblastom-Proliferation durch Angiogenese- und Apoptose-Modulation.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 796874-99-2
Sample solution is provided at 25 µL, 10mM.
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High affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM). Clears α-synuclein aggregates induced by oxidative stress in neuronal cells. Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4). Induces angiogenesis via POP inhibition. Anti-angiogenic and neuroprotective. Brain penetrant.
Yedlapudi et al (2016) Inhibition of alpha-synuclein aggregation by multifunctional Da agonists assessed by a novel in vitro assay and an in vivo Drosophila synucleinopathy model. Sci Rep. 69 38510 PMID:27917933 |Myöhänen et al (2012) A prolyl oligopeptidase inhibitor, KYP-2047, reduces alpha-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. Br.J.Pharmacol. 166 1097 PMID:22233220 |Jalkanen et al (2011) Brain pharmacokinetics of two prolyl oligopeptidase inhibitors, JTP-4819 and KYP-2047, in the rat. Basic Clin.Pharmacol.Toxicol. 109 443 PMID:21707925 |Myöhänen et al (2011) Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner. Br.J.Pharmacol. 163 1666 PMID:21133893 |Venäläinen et al (2006) Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors. Biochem.Pharmacol. 71 683 PMID:16405869
Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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