Mavoglurant racemate (AFQ-056 racemate) (Synonyms: AFQ-056 racemate) |
| Katalog-Nr.GC30303 |
Mavoglurant-Racemat (AFQ-056-Racemat) (AFQ-056-Racemat) ist das Racemat von Mavoglurant.
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Cas No.: 1636881-61-2
Sample solution is provided at 25 µL, 10mM.
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Mavoglurant (racemate) is the racemate of mavoglurant. Mavoglurant is a novel, non-competitive mGlu5 receptor antagonist.
For antagonistic activity, (-)-mavoglurant, the (-)-enantiomer shows IC50 of 0.11 μM and 0.03 μM (Ca2+ and PI-turnover) whereas the (+)-enantiomer ((+)-10) shows only 37% and 18% inhibition at 10 μM[1].
[1]. Vranesic I, et al. AFQ056/mavoglurant, a novel clinically effective mGluR5 antagonist: identification, SAR and pharmacological characterization. Bioorg Med Chem. 2014 Nov 1;22(21):5790-803
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