ML 418 |
| Katalog-Nr.GC50596 |
ML 418 ist der erste wirksame, selektive und ZNS-durchdringende Blocker des Kir7.1-Kaliumkanals (IC50, 310 nM), der auch Kir6.2/SUR1 wirksam hemmt und eine überlegene Selektivität gegenüber anderen Kir-Kanälen aufweist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1928763-08-9
Sample solution is provided at 25 µL, 10mM.
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Kir7.1 inhibitor (IC50 = 0.31 μM). Also inhibits Kir6.2 with similar potency. Displays >17-fold selectivity for Kir7.1 over Kir1.1, Kir2.1, Kir2.2, Kir2.3, Kir3.1/3.2 and Kir4.1. Active in vivo.
Swale et al (2016) ML418: the first selective, sub-micromolar pore blocker of Kir7.1 potassium channels. ACS Chem.Neurosci. 7 1013 PMID:27184474 |Kharade (2017) Pore polarity and charge determine differential block of Kir1.1 and Kir7.1 potassium channels by small-molecule inhibitor VU590. Mol.Pharmacol. 92 338 PMID:28619748
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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