MZP-55 |
Katalog-Nr.GC33363 |
MZP-55 ist ein PROTAC, verbunden durch Liganden fÜr von Hippel-Lindau und BRD3/4, mit einem Kd von 8 nM fÜr Brd4BD2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2010159-48-3
Sample solution is provided at 25 µL, 10mM.
MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2.
MZP-55 is a selective degrader of BRD3/4 based on PROTAC technology, with a Kd of 8 nM for Brd4BD2. MZP-55 binds to VHL-EloC-EloB protein (VCB) with a Kd of 105 ± 24 nM. MZP-55 shows an inhibitory activity against MV4;11 and HL60 cells, with pEC50s of 7.31 ± 0.03 and 6.57 ± 0.02, respectively[1].
[1]. Chan KH, et al. Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds. J Med Chem. 2018 Jan 25;61(2):504-513.
Average Rating: 5
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