PHPS1 (Synonyms: PTP Inhibitor V) |
| Katalog-Nr.GC44637 |
PHPS1 ist ein potenter und selektiver Shp2-Inhibitor mit Kis von 0,73, 5,8, 10,7, 5,8 und 0,47 μM fÜr Shp2, Shp2-R362K, Shp1, PTP1B bzw. PTP1B-Q.
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Cas No.: 314291-83-3
Sample solution is provided at 25 µL, 10mM.
PHPS1 is a cell-permeable, phosphotyrosine mimetic that inhibits the Src homology region 2 domain-containing phosphatase (SHP)-2 (IC50 = 2.1 µ Ki = 0.73 µM). It is selective for SHP-2, inhibiting ECPTP, PTP1B, SHP-1, and mycobacterium MptpA at relatively higher concentrations (IC50s = 5.4, 19, 30, and 39 µM, respectively). PHPS1 has been shown to inhibit SHP-2-dependent cellular signaling and tumor cell colony formation.
Reference:
[1]. Hellmuth, K., Grosskopf, S., Lum, C.T., et al. Specific inhibitors of the protein tyrosine phosphatase Shp2 identified by high-throughput docking. Proceedings of the National Academy of Sciences of the United States of America 105(20), 7275-7280 (2008).
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
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