PROTAC RAR Degrader-1 |
| Katalog-Nr.GC34740 |
PROTAC RAR Degrader-1 umfasst eine IAP-Ligandenbindungsgruppe, einen Linker und eine RAR-Ligandenbindungsgruppe. PROTAC RAR Degrader-1 ist ein RAR-Degrader. Maximaler RAR-Abbau bei einer Konzentration von 30 μM in HT1080-Zellen. Auf cIAP1 basierende Abbauinduktoren werden als spezifische und nichtgenetische IAP-abhÄngige ProteinlÖscher (SNIPERs) bezeichnet.
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Cas No.: 1351169-27-1
Sample solution is provided at 25 µL, 10mM.
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PROTAC RAR Degrader-1 comprises a cIAP1 ligand binding group, a linker and a RAR ligand binding group. PROTAC RAR Degrader-1 is an RAR degrader. Maximal RAR degradation at 30 μM concentration in HT1080 cells. Degradation inducers based on cIAP1 are called specific and non-genetic IAP-dependent protein erasers (SNIPERs)[1].
[1]. Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019 Jan 25;17:160-176.
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