SB-612111 |
| Katalog-Nr.GC39619 |
SB-612111 ist ein neuartiger und potenter Opiatrezeptor-Ähnlicher Orphan-Rezeptor (ORL-1)-Antagonist mit einer hohen AffinitÄt fÜr hORL-1 (Ki=0,33 nM).
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 371980-98-2
Sample solution is provided at 25 µL, 10mM.
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SB-612111 is a novel and potent human opiate receptor-like orphan receptor (ORL-1) antagonist with a high affinity for hORL-1 (Ki=0.33 nM). SB-612111 exhibits selectivity for μ-, κ- and δ-receptors with Ki values of 57.6 nM, 160.5 nM and 2109 nM, respecticely. SB-612111 effectively antagonizes the pronociceptive action of Nociceptin in an acute pain model[1].
[1]. Paola F Zaratin, et al. Modification of Nociception and Morphine Tolerance by the Selective Opiate Receptor-Like Orphan Receptor Antagonist (-)-cis-1-methyl-7-[[4-(2,6-dichlorophenyl)piperidin-1-yl]methyl]-6,7,8,9-tetrahydro-5H-benzocyclohepten-5-ol (SB-612111).J Pharmacol Exp Ther. 2004 Feb;308(2):454-61.
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