STAD 2 |
| Katalog-Nr.GC50501 |
STAD 2 ist ein potenter und selektiver Disruptor von PKA-RII mit einem Kd von 6,2 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1542100-77-5
Sample solution is provided at 25 µL, 10mM.
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AKAP disruptor. Selectively binds PKA-RII subunit with high affinity (Kd = 6.2 nM) and blocks its interaction with AKAP. Cell permeable. Selectively permeable to malaria-infected red blood cells and displays antimalarial activity through a PKA-independent mechanism.
Bendzunas et al (2018) Investigating PKA-RII specificity using analogs of the PKA:AKAP peptide inhibitor STAD-2. Bioorg.Med.Chem. 26 1174 PMID:29449124 |Flaherty et al (2015) The stapled AKAP disruptor peptide STAD-2 displays antimalarial activity through a PKA-independent mechanism. PLoS One 10 e0129239 PMID:26010880 |Wang et al (2014) Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. ACS Chem.Biol. 9 635 PMID:24422448
Average Rating: 5 (Based on Reviews and 18 reference(s) in Google Scholar.)
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