TH 1020 |
| Katalog-Nr.GC50374 |
TH 1020 ist ein potenter und selektiver Toll-like-Rezeptor 5 (TLR5)/Flagellin-Komplex-Antagonist mit einem IC50 von 0,85 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1841460-82-9
Sample solution is provided at 25 µL, 10mM.
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Toll-like receptor (TLR) 5/Flagellin complex antagonist (IC50 = 0.85 μM). Competes with flagellin for TLR5 binding to inhibit the TLR5:flagellin interaction and subsequent downstream TNF-α secretion.
Yan et al (2016) Pyrimidine triazole thioether derivatives as toll-like receptor 5 (TLR5)/flagellin complex inhibitors. Chem.Med.Chem. 11 822 PMID:26634412
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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