VO-OHpic |
| Katalog-Nr.GC50041 |
VO-OHPic ist ein reversibler, nicht kompetitiver und selektiver PTEN-Inhibitor mit einem IC50 von 46 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 675848-25-6
Sample solution is provided at 25 µL, 10mM.
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Potent inhibitor of PTEN (phosphatase and tensin homolog) (IC50 = 35 nM). Displays selectivity for PTEN over cysteine-based phosphatases such as SopB, MTM, PTPβ and SAC (IC50 values are 588 nM, 4.03, 57.5 and >10 μM respectively). Increases PIP2 and PIP3 levels; also increases Akt translocation in NIH/3T3 fibroblasts. Blocks the immunosuppressant activity of IDO-activated Tregs. Promotes antitumor inflammatory response in combination with immunotherapy and enhances anticancer chemotherapy in tumor-bearing mice.
Rosivatz et al (2006) A small-molecule inhibitor for phosphatase and tensin homologue deleted on chromosome 10 (PTEN). ACS Chem.Biol. 1 780 PMID:17240976 |Sharma et al (2015) The PTEN pathway in Tregs is a critical driver of the suppressive tumor microenvironment. Sci.Adv. 1 e1500845 PMID:26601142
Average Rating: 5 (Based on Reviews and 33 reference(s) in Google Scholar.)
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