Zaltoprofen (Synonyms: CN 100, Soleton) |
| Katalog-Nr.GC13626 |
Zaltoprofen (CN100), ein nicht-steroidales entzÜndungshemmendes Medikament (NSAID), ist ein bevorzugter und oral aktiver COX-2-Hemmer mit IC50-Werten von 1,3 und 0,34 μM fÜr COX-1 bzw. COX-2.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 74711-43-6
Sample solution is provided at 25 µL, 10mM.
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Zaltoprofen(CN100) is an inhibitor of COX for treatment of arthritis. Target: COXZaltoprofen, a preferential COX-2 inhibitor, exhibited a potent inhibitory action on the nociceptive responses induced by a retrograde infusion of bradykinin into the right common carotid artery in rats. Zaltoprofen had a moderate inhibitory effect compared with those of the above-mentioned NSAIDs. the inhibitory effect of zaltoprofen on bradykinin-induced nociceptive responses is not explainable by the inhibition of cyclooxygenase (COX). Zaltoprofen did not bind to B(1) and B(2) receptors in a radio-ligand binding assay. In the cultured dorsal root ganglion cells of mature mice, zaltoprofen completely inhibited the bradykinin-induced increase of [Ca(2+)](i), which was inhibited by B(2) antagonist D-Arg-[Hyp(3), Thi(5,8), D-Phe(7)]-bradykinin, but not by B(1) antagonist. [1].
References:
[1]. Hirate, K., et al., Zaltoprofen, a non-steroidal anti-inflammatory drug, inhibits bradykinin-induced pain responses without blocking bradykinin receptors. Neurosci Res, 2006. 54(4): p. 288-94.
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