(+/-) RK-682 (Synonyms: (±)-3-Hexadecanoyl-5-hydroxymethyltetronic acid) |
Katalog-Nr.GB40043 |
(±)-RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7 µM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682. Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM), HIV-1 protease (IC50 = 84 μlM), and heparanase (IC50 = 17 μM). Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity. Care should be taken when using RK-682 in the presence of metal salts - because it readily forms metal complexes that affects its phosphatase inhibitory activity. RK-682 has been identified as a potential promiscuous inhibitor.
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Cas No.: 150627-37-5
Sample solution is provided at 25 µL, 10mM.
(±)-RK-682 (150627-37-5) is a protein tyrosine phosphatase inhibitor (IC50's = 54 7 µM for CD45, 2.0 μM for VHR; did not inhibit cdc25B) originally isolated from the fermentation of Streptomyces sp. 88-682. Inhibits cell cycle at G1/S. RK-682 has also been shown to inhibit PLA2 (IC50 = 16 μM), HIV-1 protease (IC50 = 84 μlM), and heparanase (IC50 = 17 μM). Natural RK-682 (R-isomer) and synthetic racemic material have identical phosphatase activity. Care should be taken when using RK-682 in the presence of metal salts - because it readily forms metal complexes that affects its phosphatase inhibitory activity. RK-682 has been identified as a potential promiscuous inhibitor.
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