RMC-4550 |
| Katalog-Nr.GC33044 |
RMC-4550 ist ein potenter, selektiver und allosterischer Inhibitor von SHP2 mit einem IC50 von 0,583 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2172651-73-7
Sample solution is provided at 25 µL, 10mM.
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RMC-4550 is a potent, selective and allosteric inhibitor of SHP2, with an IC50 of 0.583 nM.
RMC-4550 is an allosteric inhibitor of SHP2 and stabilizes the auto-inhibited conformation of wild-type SHP2 enzyme, with a mode of inhibition similar to SHP099. Consistent with an allosteric mode of inhibition, RMC-4550 inhibits the activity of full-length wild-type SHP2 enzyme activated by a di-phosphotyrosine peptide, but lacks activity against the free catalytic domain of SHP2[1].
[1]. Nichols RJ, et al. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nat Cell Biol. 2018 Sep;20(9):1064-1073.
Average Rating: 5 (Based on Reviews and 3 reference(s) in Google Scholar.)
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