RORγt inverse agonist 13 |
Katalog-Nr.GC62349 |
RORγt inverser Agonist 13 (Verbindung 3i) ist ein potenter, oral aktiver und selektiver RORγt inverser Agonist mit verbesserten arzneimittelÄhnlichen Eigenschaften und einem IC50 von 63,8 nM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2170477-75-3
Sample solution is provided at 25 µL, 10mM.
RORγt inverse agonist 13 (Compound 3i) is a potent, orally active and selective RORγt inverse agonist, with improved drug-like properties, with an IC50 of 63.8 nM[1].
RORγt inverse agonist 13 (Compound 3i) exhibits activity with an inhibition of 76% at 0.3 µM in Th17 cell differentiation assay[1].
RORγt inverse agonist 13 (Compound 3i, 25 mg/kg, Orally, twice daily) demonstrats excellent in vivo PK profile in mice and good in vivo efficacy in an IMQ-induced psoriasis mice model[1].
[1]. Nannan Sun, et al. Discovery of carboxyl-containing biaryl ureas as potent RORγt inverse agonists. Eur J Med Chem. 2020 Jul 5;202:112536.
Average Rating: 5
(Based on Reviews and 13 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
Required fields are marked with *