Rubratoxin A (Synonyms: BRN 1633008, HSDB 3532) |
| Katalog-Nr.GC40285 |
Rubratoxin A ist ein natÜrliches Mykotoxin und ein kompetitiver Inhibitor der Proteinphosphatase 2A (PP2A) mit einem IC50 von 170 nM. Rubratoxin A bewirkt eine UnterdrÜckung von Tumormetastasen und eine Reduktion des primÄren Tumorvolumens in Maus-Xenotransplantaten.
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Cas No.: 22467-31-8
Sample solution is provided at 25 µL, 10mM.
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Rubratoxin A is a natural mycotoxin and competitive inhibitor of protein phosphatase 2A (PP2A; IC50 = 170 nM). It has no significant effect on several other phosphatases, including PP1, PP2B, and protein tyrosine phosphatase 1B. Rubratoxin A drives overphosphorylation of PP2A substrate proteins in cultured cells treated for three hours at 20 µM. It causes suppression of tumor metastasis and reduction of primary tumor volume in mouse xenografts.
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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