(S,R,S)-AHPC-Me dihydrochloride (Synonyms: VHL ligand 2 dihydrochloride; E3 ligase Ligand 1 dihydrochloride) |
| Katalog-Nr.GC60426 |
(S,R,S)-AHPC-Me-Dihydrochlorid (VHL-Ligand-2-Dihydrochlorid) ist der (S,R,S)-AHPC-basierte VHL-Ligand, der bei der Rekrutierung des von Hippel-Lindau (VHL)-Proteins verwendet wird. (S,R,S)-AHPC-Me-Dihydrochlorid kann verwendet werden, um ARV-771 zu synthetisieren, einen von Hippel-Landau (VHL) E3-Ligase-basierten BET PROTAC-Abbauer. ARV-771 baut das BET-Protein in kastrationsresistenten Prostatakrebszellen (CRPC) mit einem DC50 < 1 nM stark ab.
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Sample solution is provided at 25 µL, 10mM.
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(S,R,S)-AHPC-Me dihydrochloride (VHL ligand 2 dihydrochloride) is the (S,R,S)-AHPC-based VHL ligand used in the recruitment of the von Hippel-Lindau (VHL) protein[1]. (S,R,S)-AHPC-Me dihydrochloride can be used to synthesize ARV-771, a von Hippel-Landau (VHL) E3 ligase-based BET PROTAC degrader. ARV-771 potently degrades BET protein in castration-resistant prostate cancer (CRPC) cells with a DC50 <1 nM[2].
[1]. Raina K, et al. PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer. Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7124-9.
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