S1R agonist 2 hydrochloride |
| Katalog-Nr.GC71104 |
S1R agonist 2 hydrochloride ist ein selektiver S1R-Agonist mit Kis von 1.1 nM und 88 nM für S1R und S2R.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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S1R agonist 2 (Compound 8b; 0.1-5 μM) hydrochloride significantly increases the nerve growth factor (NGF) induced neurite outgrowth at all the tested concentrations in a dose-dependent manner[1].
S1R agonist 2 (24 h) hydrochloride significantly prevents cell damage induced by Rotenone when tested at the concentration of 1 μM in SHSY5Y cells[1].
S1R agonist 2 (0.1-5 μM; 24 h) hydrochloride demonstrates a neuroprotective effect against NMDA stimuli in SHSY5Y cells[1].
S1R agonist 2 (0-10 μM; 24-72 h) hydrochloride shows no cytotoxicity against A549, LoVo and Panc-1 cells[1].
S1R agonist 2 (Compound 8b; 0.1-50 μM; 120 h) hydrochloride does not induce embryo death (100% of embryos alive) at 10 μM, but induces the death of all zebrafish embryo at the highest dose tested (50 μM)[1].
References:
[1]. Linciano P, et al. Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents. Eur J Med Chem. 2023 Mar 5;249:115163.
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