SHS4121705 |
Katalog-Nr.GC48077 |
A mitochondrial uncoupler
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2379550-82-8
Sample solution is provided at 25 µL, 10mM.
SHS4121705 is an orally bioavailable mitochondrial uncoupler.1 It increases oxygen consumption rate in L6 rat myoblast cells with an EC50 value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH).
1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as efficacious mitochondrial uncouplers in STAM mouse model of nonalcoholic steatohepatitisJ. Med. Chem.63(11)6203-6224(2020)
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