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Sonlicromanol (Synonyms: KH176)

Katalog-Nr.GC63197

Sonlicromanol (KH176) ist ein oral aktiver Modulator fÜr reaktive Sauerstoffspezies (ROS) fÜr die Untersuchung von mitochondrialen Erkrankungen.

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Sonlicromanol Chemische Struktur

Cas No.: 1541170-75-5

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Sample solution is provided at 25 µL, 10mM.

Description Chemical Properties Product Documents Related Products

Sonlicromanol (KH176) is an orally active reactive oxygen species (ROS) modulator for the study in mitochondrial disease[1][2].

Sonlicromanol (KH176, 10 mg/kg, ip, twice daily) has promising, but independent and nonadditive, properties for the pharmacological treatment of CI-deficiency-related mitochondrial diseases[3].

[1]. X Jiang, et al. Mechanism of action and potential applications of selective inhibition of microsomal prostaglandin E synthase-1-mediated PGE 2 biosynthesis by sonlicromanol’s metabolite KH176m. Sci Rep. 2021 Jan 13;11(1):880.
[2]. Zikai Feng, et al. Comparative In Vitro Toxicology of Novel Cytoprotective Short-Chain Naphthoquinones. Pharmaceuticals (Basel). 2020 Aug 7;13(8):184.
[3]. Sanne J C M Frambach, et al. Effects of clofibrate and KH176 on life span and motor function in mitochondrial complex I-deficient mice. Biochim Biophys Acta Mol Basis Dis. 2020 Jun 1;1866(6):165727.

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