SQ609 |
| Katalog-Nr.GC62441 |
SQ609 ist eine Leitverbindung aus einer Bibliothek von Dipiperidinen. SQ609 hemmt mehr als 90 % des intrazellulÄren Bakterienwachstums bei 4μ g/ml und ist fÜr diese Zellen toxisch. SQ609 zeigt eine starke antituberkulÖse AktivitÄt.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 627052-25-9
Sample solution is provided at 25 µL, 10mM.
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SQ609 is a lead compound from a library of dipiperidines. SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells. SQ609 displays a potent antitubercular activity [1].
In Mtb-infected macrophages in vitro, SQ609 inhibits more than 90% of intracellular bacterial growth at 4μg/ml and is toxic to these cells[1].
SQ609 (10 mg/kg; intravenous injection) completely prevents weight loss in the Mtb-infected animals and prolongs the therapeutic effect following drug withdrawal for another 10-15 days[1].
[1]. Bogatcheva E, et al. Identification of SQ609 as a lead compound from a library of dipiperidines. Bioorg Med Chem Lett. 2011;21(18):5353-5357.
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