Sugammadex (Synonyms: Org25969 free acid) |
| Katalog-Nr.GC67613 |
Sugammadex ist ein synthetisches γ-Cyclodextrin-Derivat und wirkt als Aufhebungsmittel für die neuromuskuläre Blockade. Sugammadex zeigt nephroprotektive Wirkung bei Ischämie-Reperfusionsverletzung.
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Cas No.: 343306-71-8
Sample solution is provided at 25 µL, 10mM.
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Sugammadex is a synthetic γ-cyclodextrin derivative, and acts as a reversal agent for neuromuscular block. Sugammadex shows nephroprotective effect in ischemia-reperfusion injury[1][2].
Sugammadex (100 mg/kg, IV, once) has a nephroprotective effect when given at the beginning of reperfusion after one hour of ischemic condition on rats[2].
[1]. de Boer HD, et al. Sugammadex, a new reversal agent for neuromuscular block induced by rocuronium in the anaesthetized Rhesus monkey. Br J Anaesth. 2006 Apr;96(4):473-9. Epub 2006 Feb 7.
[2]. Tercan M, Y?lmaz ?nal F, Seneldir H, Kocoglu H. Nephroprotective Efficacy of Sugammadex in Ischemia-Reperfusion Injury: An Experimental Study in a Rat Model. Cureus. 2021 Jun 17;13(6):e15726.
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