Tafluprost (free acid) (Synonyms: AFP-172) |
| Katalog-Nr.GC40866 |
Tafluprost (freie SÄure) (AFP-172), eine aktive metabolische Form von Tafluprost, ist ein selektiver Prostanoid-FP-Rezeptoragonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 209860-88-8
Sample solution is provided at 25 µL, 10mM.
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A number of 17-phenyl trinor prostaglandin F2α (17-phenyl trinor PGF2α) derivatives have been approved for the treatment of glaucoma. Of these, the ones wherein the 13,14-double bond has been hydrogenated retain relatively good potency, but show a significantly reduced incidence of local irritant side effects. Alternatively, it was recently reported that analogs incorporating a 15-deoxy-15,15-difluoro modification also had a favorable ophthalmic activity profile. Tafluprost is a 2-series, 16-phenoxy analog of PGF2α with the 15,15-difluoro substitution. Tafluprost (free acid) is a very potent FP receptor agonist, with a Ki of 0.4 nM. The ester prodrug forms of tafluprost are also potent ocular hypotensives in monkeys.
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