TASP 0433864 |
Katalog-Nr.GC50150 |
TASP 0433864 ist ein selektiver positiver allosterischer Modulator (PAM) des metabotropen Glutamat-2-Rezeptors (mGlu2) mit EC50-Werten von 199 nM und 206 nM gegen menschliche bzw. Ratten-mGlu2-Rezeptoren.
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Cas No.: 1431980-60-7
Sample solution is provided at 25 µL, 10mM.
Selective mGlu2 receptor positive allosteric modulator (EC50 values are 199 and 206 nM for human and rat receptors, respectively). Exhibits negligible activity against a range of neurotransmitter targets, except 5-HT2B and MAO-B (72 and 92% inhibition at 10 μM, respectively). Potentiates inhibitory effect of DCG IV on excitatory postsynaptic potentials in hippocampal slices and ketamine- and methamphetamine-induced increases in locomotor activity in rats and mice.
Hiyoshi et al (2014) Neurophysiologic and antipsychotic profiles of TASP0433864, a novel positive allosteric modulator of metabotropic glutamate 2 receptor. J.Pharmacol.Exp.Ther. 351 642 PMID:25277141
Average Rating: 5
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