Terevalefim (Synonyms: ANG-3777) |
| Katalog-Nr.GC63215 |
Terevalefim (ANG-3777), ein Mimetikum des Hepatozytenwachstumsfaktors (HGF), aktiviert selektiv den c-Met-Rezeptor.
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Cas No.: 1070881-42-3
Sample solution is provided at 25 µL, 10mM.
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Terevalefim (ANG-3777), an hepatocyte growth factor (HGF) mimetic, selectively activates the c-Met receptor[1][2].
Terevalefim (ANG-3777) (0-10 μM) significantly inhibited cancer cells proliferation in HUVECs[2].
Terevalefim (ANG-3777) decreases apoptosis, increases proliferation, and promotes organ repair and function in animal models[1].Terevalefim (ANG-3777, 40 mg/kg, IP) phosphorylates the c-Met receptor in rats[2].
[1]. Jonathan S Bromberg, et al. Renal Function Improvement Following ANG-3777 Treatment in Patients at High Risk for Delayed Graft Function After Kidney Transplantation. Transplantation. 2021 Feb 1;105(2):443-450.
[2]. Latha Paka, et al. The Effect of ANG-3777 on Hepatocyte Growth Factor Receptor, c-MET Signaling. American Transplant Society.
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